Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Refractory Hypoxemia in an Asymptomatic 6-Year-Old: It is not Always the Heart.

Clinical pediatrics·2025
Same author

Trends in transgender healthcare curricula in graduate medical education.

Proceedings (Baylor University. Medical Center)·2023
Same author

Validation of the Reveal® 3-D for Gluten Assay for Detection of Gluten in Clean-in-Place Rinses and Stainless Steel Environmental Surfaces: AOAC Performance Tested MethodSM 122201.

Journal of AOAC International·2023
Same author

<i>Listeria</i> meningitis associated with tonsillar herniation in an immunocompetent school-aged child.

BMJ case reports·2023
Same author

Validation of Modifications to the Soleris®E. coli Method for Detection and Threshold Determination of Escherichia coli in Select Foods: Level 3 Modification to AOAC Performance Tested MethodSM 101101.

Journal of AOAC International·2021
Same author

Hydrogen Peroxide Induced Colitis: A Case Report and Literature Review.

Case reports in gastrointestinal medicine·2018

Related Experiment Video

Updated: May 7, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Cushing syndrome.

Bibek Bista1, Nancy Beck

  • 1Department of Pediatrics, Texas Tech University Health Sciences Center, 3601 - 4th Street, Mail Stop 9406, Lubbock, TX, 79430, USA.

Indian Journal of Pediatrics
|September 25, 2013
PubMed
Summary
This summary is machine-generated.

Cushing syndrome, caused by excess glucocorticoids, most often in children is from medication. Key signs include growth retardation and obesity, aiding diagnosis in pediatric patients.

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Related Experiment Videos

Last Updated: May 7, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Area of Science:

  • Pediatric Endocrinology
  • Endocrinology
  • Clinical Medicine

Background:

  • Cushing syndrome results from prolonged exposure to glucocorticoids.
  • In children and adolescents, exogenous glucocorticoid administration is the most frequent cause.
  • Common symptoms include weight gain, growth retardation, hirsutism, obesity, striae, acne, and hypertension.

Purpose of the Study:

  • To outline the clinical presentation of Cushing syndrome in pediatric populations.
  • To differentiate Cushing syndrome from childhood obesity based on growth patterns.
  • To describe diagnostic approaches and age-related considerations for pediatric Cushing syndrome.

Main Methods:

  • Clinical feature analysis for Cushing syndrome in children and adolescents.
  • Diagnostic strategy formulation based on ACTH-dependency and age.
  • Review of treatment modalities and long-term follow-up care.

Main Results:

  • Severe linear growth diminution is a hallmark symptom, aiding in differential diagnosis with childhood obesity.
  • Diagnostic pathways focus on distinguishing ACTH-dependent from ACTH-independent causes.
  • Treatment is etiology-dependent, with post-cure care focusing on growth and development.

Conclusions:

  • Cushing syndrome in pediatric patients presents with distinct features, including significant growth impairment.
  • Accurate diagnosis relies on differentiating etiology (ACTH-dependent vs. independent) and age-specific assessment.
  • Comprehensive management includes targeted treatment and vigilant monitoring of linear growth, pubertal progression, and body composition post-cure.