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Updated: May 7, 2026

Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
Peritoneal mesothelioma in a jaguar (Panthera onca)
Francisco de Assis Leite Souza1, Ciro José Sousa de Carvalho, Hatawa M de Almeida
1Division of Animal Pathology, Department of Veterinary Medicine and Surgery, Center of Agrarian Sciences, Campus da Socopo, Universidade Federal do Piaui, CEP 64049-550, Teresina-PI, Brazil.
Abstract:
A 21-yr-old female jaguar (Panthera onca) died in a zoo in Teresina, Piaui, Brazil, following a history of abdominal distension, ascites, anorexia, and dyspnea. At necropsy, a dark red, watery, blood-tinged serous fluid was present in the abdominal cavity. The peritoneum was thick with firm, yellow, villous projections. Histologically, the tumors were composed of a biphasic population of cells, which reacted to anti-cytokeratin and anti-vimentin antibodies, consistent with a biphasic benign mesothelioma of peritoneal origin. This is the first reported case of mesothelioma in a captive jaguar.
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