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Updated: May 7, 2026

Development of a Neonatal Rat Model for Brachial Plexus Birth Injury
Published on: March 27, 2026
Bilateral carpal contracture in a neonatal addax (Addax nasomaculatus)
Megan K Watson1, Jennifer Langan, Michael J Adkesson
1University of Illinois, College of Veterinary Medicine, 1008 W. Hazelwood Drive, Urbana, Illinois 65102, USA. megan.k.watson@gmail.com
Abstract:
A neonate male addax calf displayed an inability to extend its forelimbs bilaterally (range of motion restricted to 45 degrees-50 degrees on full extension) with resultant inability to stand. Based on examination and radiographs, the congenital defect was attributed to contracted soft tissue structures (joint capsule and/or intercarpal ligaments). Splinting, support of the limbs, and physical therapy resulted in moderate improvement of the angle of contraction (full flexion to approximately 120 degrees on extension at day 10). The animal was able to walk with splints but died at 10 days from acute head trauma, presumably related to a traumatic fall caused by challenges with ambulation. Postmortem examination confirmed soft-tissue contracture of the forelimbs. Malposition of the calf in utero was considered a possible cause of the defect.

