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Updated: May 7, 2026

Design of a Biaxial Mechanical Loading Bioreactor for Tissue Engineering
Published on: April 25, 2013
[Research progress of bioreactor biophysical factors in cartilage tissue engineering]
Gang Ye1, Fangbiao Zhang, Hongcan Shi
1Department of General Thoracic Surgery, Medical College of Yangzhou University, Yangzhou Jiangsu, 225001, P.R.China.
Objective:
To review the recent research progress of the bioreactor biophysical factors in cartilage tissue engineering.
Methods:
The related literature concerning the biophysical factors of bioreactor in cartilage tissue engineering was reviewed, analyzed, and summarized.
Results:
Oxygen concentration, hydrostatic pressure, compressive force, and shear load in the bioreactor system have no unified standard parameters. Hydrostatic pressure and shear load have been in controversy, which restricts the application of bioreactors.
Conclusion:
The biophysical factors of broreactor in cartilage tissue engineering have to be studied deeply.

