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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

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Cancer: tilting at windmills?

Prakash Kulkarni1, Takumi Shiraishi, Rahul V Kulkarni

  • 1Department of Urology, The Johns Hopkins University School of Medicine, 600 N Wolfe St, 105B Marburg, 21287, Baltimore, MD, USA. pkulkar4@jhmi.edu.

Molecular Cancer
|September 26, 2013
PubMed
Summary

Cancer

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Cancer cells exhibit phenotypic diversity and adaptability, crucial for survival.
  • Phenotypic changes, like drug resistance, are traditionally linked to genomic mutations.
  • Emerging evidence challenges the purely mutation-driven model of cancer development.

Discussion:

  • This commentary proposes that stochasticity within protein interaction networks (PINs) drives cancer initiation and progression.
  • It challenges the deterministic view solely based on genetic mutations.
  • The role of intrinsically disordered proteins (IDPs) in this stochasticity is highlighted.

Key Insights:

  • Stochasticity in protein interaction networks offers an alternative explanation for cancer development.

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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle
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Co-Culture In Vitro Systems to Reproduce the Cancer-Immunity Cycle

Published on: June 7, 2024

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

  • Intrinsically disordered proteins (IDPs) are implicated as key players in cancer's non-mutational aspects.
  • Cancer's adaptability may stem from dynamic network behavior rather than solely genetic alterations.

    • Outlook:

    • Targeting intrinsically disordered proteins (IDPs) may unlock novel therapeutic strategies.
    • Further research into protein network dynamics can refine our understanding of cancer.
    • This perspective could lead to new treatment protocols for various cancers.