Related Experiment Video
Updated: May 7, 2026
10:37
Cultivation Methods of Spirochetes from Borrelia burgdorferi Sensu Lato Complex and Relapsing Fever Borrelia
Published on: November 25, 2022
Fever in Behçet's syndrome.
Emire Seyahi1, Huseyin Karaaslan, Serdal Ugurlu
1University of Istanbul, Cerrahpasa Medical Faculty, Department of Rheumatology, University of Istanbul, Turkey. eseyahi@yahoo.com.
Clinical and Experimental Rheumatology
|September 26, 2013
Summary
Fever is reported in 22% of Behçet's syndrome (BS) patients, often linked to vascular or neurological issues. However, measured temperatures in active BS cases showed only a modest increase compared to healthy controls.
Area of Science:
- Rheumatology
- Immunology
- Internal Medicine
Background:
- Fever is considered uncommon in Behçet's syndrome (BS), typically associated with vascular disease.
- This study aimed to investigate the prevalence and characteristics of fever in BS patients.
Purpose of the Study:
- To determine the frequency of fever episodes in Behçet's syndrome (BS) patients.
- To explore the association between fever and major organ involvement in BS.
- To measure body temperature in BS patients with active lesions.
Main Methods:
- A questionnaire-based survey of 500 BS patients, 94 with familial Mediterranean fever (FMF), 100 with ankylosing spondylitis (AS), 72 with systemic lupus erythematosus (SLE), and 100 healthy controls (HC) for fever history.
- Body temperature measurement in 98 newly diagnosed BS patients with active lesions and 61 HC, with temperature recorded thrice.
Main Results:
- 22% of BS patients reported a history of fever, compared to 87% in FMF, 33% in SLE, and 8% in AS. No HC reported fever.
- Fever history in BS patients correlated with vascular, neurological, or joint involvement.
- Mean body temperature in BS patients (36.72±0.42ºC) was statistically higher, though modestly, than in HC (36.56±0.27ºC).
Conclusions:
- A history of fever episodes was reported by 22% of Behçet's syndrome patients.
- Fever in BS is strongly associated with major organ involvement, including vascular, neurological, and joint systems.
- The temperature elevation associated with active BS lesions is generally modest.
Related Concept Videos
01:25Increased Body Temperature
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in response to an infection or illness.
01:26Patterns of Fever
Before understanding the types and patterns of fever, it is essential to know its phases.
01:25Types of Fever
Fever can be triggered by several factors, including infections, nervous system disorders, certain cancers, blood diseases like leukemia, embolism, thrombosis, heatstroke, dehydration, surgical trauma, crushing injuries, and allergic reactions.
Here are the different types of fever:
Here are the different types of fever:
01:22Methods of reducing fever
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
01:25Acute Inflammation II: Local and Systemic Effects
Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
01:19Homeostatic Imbalances in Body Temperature
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...