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Chromosomal mapping of the murine c-abl proto-oncogene by in situ hybridization
L Trakhtenbrot1, Z Kelman, V Rotter
1Department of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel.
Leukemia
|February 1, 1990
Abstract:
Deletion and rearrangement of chromosome 2 were shown to be major cytogenetic characteristics of radiation-induced murine myeloid leukemias. Analysis of the localization of the murine protooncogene c-abl, previously assigned by Goff et al. to chromosome 2, was done using the in situ hybridization method. The c-abl was located close to the centromere, within bands 2A-2B. This site does not correspond to the common characteristic deleted segments (2C-2D) predominantly observed in radiation induced murine myeloid leukemias.