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Updated: May 7, 2026
07:25
Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice
Published on: September 25, 2019
[Reactivation of hepatitis B associated with immunosuppression]
1Service de gastroentérologie et hépatologie, Département des spécialités de médecine, HUG, 1211 Genève 14. nicolas.goossens@hcuge.ch
Revue Medicale Suisse
|September 27, 2013
Summary
Hepatitis B virus (HBV) reactivation is a risk for immunosuppressed patients, especially those with HBs antigen positivity or undergoing certain treatments. Prophylactic antiviral therapy is crucial for preventing severe hepatitis flares in high-risk individuals.
Area of Science:
- Hepatology
- Virology
- Immunology
Context:
- Hepatitis B virus (HBV) poses a significant risk for viral reactivation and flares in immunosuppressed patient populations.
- Key risk factors for HBV reactivation include HBs antigen positivity, rituximab therapy, onco-haematological conditions, and bone marrow transplantation.
Purpose:
- To highlight the risks of hepatitis B virus reactivation in immunosuppressed patients.
- To identify factors contributing to HBV reactivation.
- To emphasize the importance of prophylactic antiviral therapy.
Summary:
- Immunosuppression increases the likelihood of hepatitis B virus (HBV) reactivation and subsequent flares.
- Positive HBs antigen, rituximab, onco-haematological diseases, and bone marrow transplants are identified as significant risk factors.
- Prophylactic antiviral treatment is recommended for high-risk patients to mitigate HBV-related complications.
Impact:
- Prophylactic antiviral therapy significantly reduces the morbidity and mortality associated with viral hepatitis flares in at-risk patients.
- Early intervention strategies can improve outcomes for immunosuppressed individuals susceptible to HBV reactivation.
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