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Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Molecular mechanisms of ETS transcription factor-mediated tumorigenesis

Adwitiya Kar1, Arthur Gutierrez-Hartmann

  • 1Cancer Biology Training Program .

Critical Reviews in Biochemistry and Molecular Biology
|September 27, 2013
PubMed

Insights

The E26 transformation-specific (ETS) transcription factors are crucial for cell functions, but their deregulation drives cancer development through various mechanisms. Targeting these ETS factors offers potential therapeutic strategies for various cancers.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • E26 transformation-specific (ETS) transcription factors regulate critical cellular processes including development, differentiation, proliferation, apoptosis, and tissue remodeling.
  • Deregulation of ETS proteins, through overexpression, gene fusions, or RAS/MAPK pathway modulation, disrupts normal cell functions, leading to uncontrolled proliferation, angiogenesis, invasion, and metastasis.
  • ETS proteins influence both epithelial and stromal compartments, with essential crosstalk for normal development and cancer progression.

Purpose of the Study:

  • To review the diverse mechanisms by which cancer-associated ETS factors contribute to carcinogenesis.
  • To highlight the role of ETS proteins in both normal physiology and cancer development.
  • To discuss potential therapeutic strategies targeting ETS factors for cancer treatment.

Main Methods:

  • Literature review focusing on ETS factors implicated in cancer development.
  • Analysis of mechanisms of ETS protein deregulation and their downstream effects.
  • Synthesis of information on ETS protein involvement in epithelial-stromal interactions.

Main Results:

  • ETS protein deregulation is linked to key hallmarks of cancer, including sustained proliferation and metastasis.
  • ETS factors play diverse roles in carcinogenesis, affecting multiple cellular pathways.
  • Targeting ETS factors presents a promising avenue for novel cancer therapeutics.

Conclusions:

  • ETS transcription factors are pivotal in cancer development, acting through varied mechanisms.
  • Understanding the complex roles of ETS proteins in cancer is crucial for therapeutic development.
  • Targeting ETS factors represents a viable strategy for future cancer therapies.

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