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The interplay between lipids and dopamine on α-synuclein oligomerization and membrane binding

Chi L L Pham, Roberto Cappai

    Bioscience Reports
    |September 27, 2013
    PubMed
    Summary

    Lipids prevent the formation of toxic alpha-synuclein:dopamine oligomers implicated in Parkinson's disease. These oligomers, once formed, cannot interact with cell membranes, suggesting a protective mechanism against neurodegeneration.

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