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[Expression of pin1 in endometrial carcinoma and its relation with PR]
Yan Tian1, Yi Zhang, Jingjing Yu
1Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha Hunan, 410078, China.E-mail: lilithtian@163.com.
Objective:
To investigate the clinicopathologic significance of pin1 and PR in patients with endometrial adenocarcinoma.
Methods:
The expression of pin1 and PR were investigated by immunohistochemistry in a total of 50 endometrial adenocarcinoma specimens.
Results:
Pin1 was over expressed in 66% (33/50) of the cases. The expression rate decreased gradually with tumor differentiation(P<0.05). In addition, pin1 expression was negatively correlated with lymph node metastasis and invasive depth of myometrium. Moreover, pin1 was positively correlated with PR expression.
Conclusion:
Our results suggest that pin1 may play important roles in the tumorigenesis and migration of endometrial cancer. Pin1 expression may be considered as a prognostic marker as PR in patients with endometrial cancer.
