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Position-effect Variegation02:32

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Live-imaging of the Drosophila Pupal Eye
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Switching cell fates in the developing Drosophila eye.

Yannis Emmanuel Mavromatakis1, Andrew Tomlinson

  • 1Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.

Development (Cambridge, England)
|September 27, 2013
PubMed
Summary

Ectopic expression of Lozenge (Lz) in Drosophila eye development precluster cells, combined with receptor tyrosine kinase (RTK) and Notch (N) signaling, successfully specified cell fates. This demonstrates Lz

Keywords:
Cell fateDrosophilaEyeLozengeR7

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Preparation of Adult Drosophila Eyes for Thin Sectioning and Microscopic Analysis
07:49

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Area of Science:

  • Developmental biology
  • Cell signaling
  • Genetics

Background:

  • Drosophila ommatidium development involves two distinct pattern formation waves.
  • The second wave relies on receptor tyrosine kinase (RTK) and Notch (N) signaling for cell fate specification.
  • The transcription factor Lozenge (Lz) is exclusively expressed in second wave cells.

Purpose of the Study:

  • To investigate the role of Lozenge (Lz) in Drosophila ommatidium development.
  • To determine if ectopic Lz expression can specify cell fates in precluster cells.
  • To validate the RTK/N signaling code for cell fate specification.

Main Methods:

  • Ectopic expression of Lz in precluster cells.
  • Simultaneous application of various RTK/N signaling codes.
  • Analysis of molecular markers for second wave cell types.

Main Results:

  • Ectopic Lz and RTK/N signaling successfully reproduced molecular markers of second wave cell types in precluster cells.
  • Confirmed Lz as a key intrinsic factor for second wave cell identity.
  • Demonstrated the accuracy of the RTK/N signaling code for cell fate specification.
  • Showed that RTK/N signaling and Lz require only transient exposure for cell fate specification.

Conclusions:

  • A combined code of extrinsic RTK/N signals and intrinsic Lz information specifies cell fates.
  • The RTK/N signaling pathway accurately directs cell fate determination.
  • Transient signaling is sufficient for developmental fate specification in Drosophila ommatidium development.