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Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice
Published on: February 22, 2019
Severe pertussis in newborns and young vulnerable infants
Gustavo Rocha1, Filipa Flôr-de-Lima, Paulo Soares
1From the *Division of Neonatology, Department of Pediatrics, Hospital de São João; †Faculty of Medicine, Porto University; ‡Division of Neonatology, Maternidade Júlio Dinis; §Neonatal and Pediatric Intensive Care Unit, Hospital Geral de Santo António; ¶Division of Neonatology, Department of Pediatrics, Centro Hospitalar de Vila Nova de Gaia; ‖Neonatal Intensive Care Unit, Department of Pediatrics, Hospital Pedro Hispano, Matosinhos, Porto; and **Neonatal Intensive Care Unit, Department of Pediatrics, Hospital de Braga, Braga, Portugal.
Abstract:
A retrospective chart review of 18 nonvaccinated newborns and infants admitted to 6 intensive care units in the north of Portugal between 2007 and 2012 revealed a high rate of admissions in 2012 along with significant rates of severe pulmonary hypertension and mortality. Hyperleukocytosis was significantly associated with a more severe clinical picture and mortality.
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