Related Experiment Video
Updated: May 7, 2026
05:05
Technique of Conjunctival Biopsy and Direct Immunofluorescence for Diagnosing Mucous Membrane Pemphigoid
Published on: June 17, 2025
Cutaneous mucinosis in mixed connective tissue disease
Maria Helena Sampaio Favarato1, Sofia Silveira de Castro Miranda, Maria Teresa Correia Caleiro
1Internal Medicine Department, University of São Paulo, São Paulo(SP),Brazil.
Anais Brasileiros De Dermatologia
|September 27, 2013
Summary
This study reports the first cases of cutaneous mucinosis, a skin condition, in patients with mixed connective tissue disease. These findings expand the understanding of connective tissue disease manifestations.
Area of Science:
- Dermatology
- Rheumatology
- Connective Tissue Diseases
Background:
- Cutaneous mucinosis involves mucin accumulation in the skin, typically associated with connective tissue diseases.
- It has not been previously documented in association with mixed connective tissue disease (MCTD).
Observation:
- Two patients with established MCTD in remission presented with distinct forms of cutaneous mucinosis: papular and reticular erythematous.
- Both cases exhibited isolated skin lesions without other systemic or laboratory abnormalities.
Findings:
- This is the first documented evidence of cutaneous mucinosis occurring in patients with MCTD.
- One patient responded to azathioprine, while the other showed improvement with chloroquine and prednisone combination therapy.
Implications:
- These cases suggest a potential, previously unrecognized association between cutaneous mucinosis and MCTD.
- Further research is warranted to elucidate the pathogenesis and diagnostic criteria for mucinosis in MCTD patients.
Related Concept Videos
01:23Skin Diseases and Disorders
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
01:23Cystic Fibrosis: Pathogenesis
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation, but...