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Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Related Experiment Video

Updated: May 7, 2026

Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

Published on: May 17, 2024

Infant macronutrient composition is associated with differences in cardiovascular structures and function in

Edith H van den Hooven¹, Layla L de Jonge, Jessica C Kiefte-de Jong

¹Departments of Epidemiology.

The Journal of Nutrition

|September 27, 2013

Summary

Infant diets rich in fat were linked to stiffer arteries, while carbohydrates were associated with lower stiffness. Early nutrition impacts childhood cardiovascular development and may influence future heart disease risk.

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Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

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Last Updated: May 7, 2026

Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

Concurrent Collection of Fetal Murine Brain and Serum to Assess Effects of Maternal Diet on Nutrition and Neurodevelopment in Neurofibromatosis Type 1

Published on: May 17, 2024

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

Area of Science:

Pediatrics
Cardiology
Nutritional Science

Background:

Early-life nutrition is crucial for cardiovascular development.
Limited understanding exists regarding infant dietary composition and childhood cardiovascular risk factors.

Purpose of the Study:

To investigate associations between infant macronutrient intake and cardiovascular structure/function at age 6.
To identify potential early dietary influences on cardiovascular health.

Main Methods:

Prospective cohort study of 2882 children.
Macronutrient intake assessed at 14 months via food-frequency questionnaires.
Cardiovascular parameters (blood pressure, pulse wave velocity, cardiac structures) measured at age 6.

Main Results:

Higher total fat intake correlated with increased carotid-femoral pulse wave velocity (PWV).
Higher carbohydrate intake associated with lower PWV.
Fat intake linked to smaller left atrial diameter; carbohydrate intake linked to larger left atrial diameter.
Higher mono- and disaccharide intake associated with increased left ventricular mass.

Conclusions:

Infant macronutrient composition may influence childhood cardiovascular development.
Dietary patterns in infancy could have long-term implications for cardiovascular risk.
Further research is needed to confirm long-term cardiovascular disease risk implications.