[Fecal transfusion as treatment of Clostridium difficile infection]

Clostridium difficile is the major identified cause of antibiotic-associated diarrhea. Metronidazole has been applied as the first-line treatment, while vancomycin has been used in recurring cases of the disease. Fecal transfusion has already long been applied as experimental therapy in the treatment of recurring C. difficile infection. The aim of fecal transfusion is normalization of the intestinal microbial flora. An only recently published extensive Finnish patient series and a randomized study have confirmed fecal transfusion as a highly efficient and safe form of treatment in recurrent C. difficile infection.