Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

cGAS/STING sensing in dendritic cells discriminates between daptomycin sensitive and resistant <i>Staphylococcus aureus</i> clinical isolates.

iScience·2026
Same author

Functional immune profiling reveals CD4<sup>+</sup> T cell dysregulation in coeliac disease.

Immunology and cell biology·2026
Same author

Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages.

EMBO reports·2026
Same author

LCMV-mediated loss of virtual memory CD8 T cells yields a functionally enhanced T cell subset.

iScience·2025
Same author

LeGO-3D: 3D imaging of lung metastases and vascularisation using light sheet fluorescence microscopy.

Npj imaging·2025
Same author

Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness.

Science advances·2025
Same journal

The roles and diversity of alarmins in the mucosae.

Advances in immunology·2026
Same journal

Principles of resident tissue macrophages revealed by the eye.

Advances in immunology·2026
Same journal

Beyond suppression: Treg specialization in infection and tissue repair.

Advances in immunology·2026
Same journal

Ontogeny and function of microglia and nerve-associated macrophages.

Advances in immunology·2025
Same journal

Neuroimmunology beyond the CNS: Nerve-macrophage interactions in peripheral tissues.

Advances in immunology·2025
Same journal

Modulation of humoral immunity by γδ T cells: A potential adjuvant strategy for vaccination.

Advances in immunology·2025
See all related articles

Related Experiment Video

Updated: May 7, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Plasmacytoid dendritic cell development.

Ken Shortman1, Priyanka Sathe, David Vremec

  • 1The Walter and Eliza Hall Institute, Melbourne, Australia; Centre for Immunology, Burnet Institute, Melbourne, Australia.

Advances in Immunology
|September 28, 2013
PubMed
Summary
This summary is machine-generated.

Plasmacytoid dendritic cells (pDC) arise from diverse developmental pathways, including lymphoid and myeloid routes. These pathways converge to form pDC, suggesting a distinct hematopoietic lineage separate from myeloid or lymphoid cells.

Keywords:
Dendritic cell developmentDendritic cell lineageDendritic cell precursorInterferonPlasmacytoid dendritic cell

More Related Videos

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System
08:18

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System

Published on: November 23, 2015

Related Experiment Videos

Last Updated: May 7, 2026

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors
13:34

Assessing the Development of Murine Plasmacytoid Dendritic Cells in Peyer's Patches Using Adoptive Transfer of Hematopoietic Progenitors

Published on: March 17, 2014

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro
06:12

Study of Dendritic Cell Development by Short Hairpin RNA-Mediated Gene Knockdown in a Hematopoietic Stem and Progenitor Cell Line In vitro

Published on: March 7, 2022

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System
08:18

In Vitro Generation of Murine Plasmacytoid Dendritic Cells from Common Lymphoid Progenitors using the AC-6 Feeder System

Published on: November 23, 2015

Area of Science:

  • Immunology
  • Developmental Biology
  • Hematopoiesis

Background:

  • Plasmacytoid dendritic cells (pDC) are crucial interferon-producing immune cells.
  • pDC differentiation in mice shares developmental links with conventional dendritic cells (cDC).
  • Multiple developmental pathways contribute to the steady-state pDC population.

Purpose of the Study:

  • To investigate the diverse developmental origins of pDC.
  • To clarify the relationship between pDC and cDC development.
  • To determine if pDC represent a distinct hematopoietic lineage.

Main Methods:

  • Analysis of distinct developmental pathways for pDC and cDC.
  • Examination of immunoglobulin heavy chain (IgH) gene rearrangements in pDC.
  • Assessment of RAG-1 expression in DC precursors.
  • Identification of pDC-like cells lacking key pDC markers.

Main Results:

  • Both lymphoid and myeloid pathways can generate pDC.
  • Some pDC pathways involve lymphoid-like precursors with IgH gene rearrangements.
  • Other pathways produce pDC without IgH rearrangements or pDC-like cells that are cDC precursors.
  • pDC development overrides lineage biases, indicating convergent differentiation.
  • DC fate can be determined early, suggesting a distinct hematopoietic lineage.

Conclusions:

  • pDC arise from multiple, distinct developmental routes.
  • Convergent differentiation leads to the pDC phenotype.
  • pDC, along with other dendritic cells, likely represent a separate hematopoietic lineage.