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Updated: May 7, 2026

Osmotic Minipump Implantation for Increasing Glucose Concentration in Mouse Cerebrospinal Fluid
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Insulin, cognition, and dementia.

Brenna Cholerton1, Laura D Baker2, Suzanne Craft2

  • 1Department of Psychiatry and Behavioral Science, University of Washington School of Medicine, Seattle, WA, USA; Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

European Journal of Pharmacology
|September 28, 2013
PubMed
Summary

Insulin resistance is linked to cognitive decline and Alzheimer's disease. Improving brain insulin sensitivity may offer new therapeutic strategies for dementia prevention and treatment.

Keywords:
AgingAlzheimer's diseaseCognitionDiabetesInsulin

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Gerontology

Background:

  • Cognitive disorders, particularly Alzheimer's disease, pose significant societal challenges.
  • Pathological changes preceding dementia often begin years before symptom onset.
  • Insulin plays a crucial role in brain function and cognitive health.

Purpose of the Study:

  • To review the role of insulin in the brain.
  • To explore the link between insulin resistance and dementia.
  • To discuss therapeutic strategies targeting brain insulin sensitivity.

Main Methods:

  • Literature review of current understanding.
  • Analysis of neuropathological mechanisms.
  • Examination of experimental therapeutic approaches.

Main Results:

  • Insulin resistance is associated with chronic conditions that increase dementia risk.
  • Rising prevalence of insulin resistance-related conditions correlates with increasing dementia rates.
  • Pharmacological interventions targeting insulin sensitivity show therapeutic potential.

Conclusions:

  • Brain insulin resistance is a significant factor in cognitive decline and dementia.
  • Enhancing brain insulin sensitivity presents a promising therapeutic avenue for Alzheimer's disease and other cognitive disorders.
  • Further research into novel therapeutic strategies is warranted.