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Relationship between C-reactive protein and kidney stone prevalence
Jonathan Shoag1, Brian H Eisner1
1Departments of Urology, New York-Presbyterian Hospital, Weill Cornell Medical College, New York, New York, and Massachusetts General Hospital, Harvard Medical School (BHE), Boston, Massachusetts.
The Journal of Urology
|September 28, 2013
Summary
Higher C-reactive protein levels are linked to increased lifetime kidney stone prevalence in younger adults. This inflammation marker may play a role in kidney stone formation in individuals aged 20-39.
Area of Science:
- Urology
- Nephrology
- Inflammation Research
Background:
- Kidney stones affect a significant portion of the population.
- Inflammation is increasingly recognized as a factor in various chronic diseases.
Purpose of the Study:
- To investigate the association between serum C-reactive protein (CRP) levels and the lifetime prevalence of kidney stones.
- To explore potential links between inflammation and kidney stone formation, particularly in different age groups.
Main Methods:
- A cross-sectional study utilizing data from the National Health and Nutrition Examination Survey (NHANES) 2007-2009.
- Analysis included 11,033 participants, examining serum C-reactive protein quintiles against self-reported kidney stone history.
Main Results:
- A strong univariate correlation was observed between C-reactive protein quintiles and kidney stone history.
- Multivariate logistic regression revealed a significant relationship between higher C-reactive protein and kidney stones in younger adults (20-39 years).
- Specifically, individuals in the third and fifth CRP quintiles showed significantly higher odds of lifetime kidney stones.
Conclusions:
- Serum C-reactive protein is significantly associated with self-reported kidney stones in younger adults.
- These findings suggest a potential role for inflammation in the pathogenesis of kidney stones in this demographic.
- Further research is warranted to elucidate the underlying mechanisms connecting C-reactive protein and kidney stone development.
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