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Related Concept Videos

Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Disorders of the Autonomic Nervous System01:18

Disorders of the Autonomic Nervous System

The autonomic nervous system (ANS) is an intricate network of nerves that controls functions such as the regulation of heart rate, digestion, and blood pressure regulation. When this system malfunctions, it can lead to various disorders that affect multiple bodily functions. One common feature of many autonomic disorders is the involvement of smooth blood vessels, which play a crucial role in regulating blood flow throughout the body.
Raynaud's disease, also known as Raynaud's phenomenon, is a...
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness, disability,...
Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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Related Experiment Video

Updated: May 7, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Negative affect in systemic sclerosis.

Leticia Leon1, Lydia Abasolo, Marta Redondo

  • 1Rheumatology Department, Hospital Clínico San Carlos, Calle Martín Lagos s/n, 28040, Madrid, Spain, lleon.hcsc@salud.madrid.org.

Rheumatology International
|September 28, 2013
PubMed
Summary

Systemic sclerosis patients experience high levels of negative emotions like depression and anxiety. Disease symptoms and appearance concerns correlate with these emotions, highlighting the need for integrated care.

Related Experiment Videos

Last Updated: May 7, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Area of Science:

  • Rheumatology
  • Psychiatry
  • Clinical Psychology

Background:

  • Negative affect is common in rheumatic diseases.
  • Prevalence and impact in systemic sclerosis (SSc) are understudied.
  • Existing research on SSc psychological comorbidities is inconclusive.

Purpose of the Study:

  • To systematically review the prevalence and predictors of negative emotions in SSc patients.
  • To compare emotional distress in SSc patients with healthy populations and other rheumatic diseases.

Main Methods:

  • Comprehensive literature search of PubMed, Medline, and PsycINFO databases up to April 2013.
  • Inclusion of 48 original research studies in the systematic review.
  • Analysis of depression, anxiety, and anger in SSc patients.

Main Results:

  • Systemic sclerosis patients exhibit significantly higher levels of negative emotions compared to controls.
  • Depression and anxiety are the most studied negative emotions in SSc; anger is under-researched.
  • Disease symptoms (joint, GI, respiratory, digital ulcers) and appearance factors correlate with negative emotions.

Conclusions:

  • Systemic sclerosis is associated with substantial psychological distress.
  • Interdisciplinary and biopsychosocial approaches are recommended for managing SSc patients.
  • Further research is needed to explore predictors and interventions for negative emotions in SSc.