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Related Experiment Video

Updated: Jun 10, 2026

Guidelines and Experience Using Imaging Biomarker Explorer (IBEX) for Radiomics
10:17

Guidelines and Experience Using Imaging Biomarker Explorer (IBEX) for Radiomics

Published on: January 8, 2018

Toward a standardized and interoperable imaging biomarker catalog.

Pablo Rodríguez-Belenguer1, Paula Doria-Borrell1, Ángel Alberich-Bayarri2

  • 1Biomedical Imaging Research Group (GIBI230), Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain.

Insights Into Imaging
|June 9, 2026
PubMed
Summary

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A new catalog structure standardizes imaging biomarkers for better research and clinical use. This FAIR-compliant system enhances discovery, comparison, and integration of biomarkers across various domains.

Area of Science:

  • Biomedical Imaging
  • Biomarker Discovery
  • Data Standardization

Background:

  • Imaging biomarkers are crucial for assessing health and disease but suffer from variability.
  • Existing inventories lack standardization, hindering systematic discovery and adoption.
  • A FAIR (Findable, Accessible, Interoperable, Reusable)-compliant catalog is needed.

Purpose of the Study:

  • To define essential variables for describing imaging biomarkers.
  • To develop a FAIR-compliant catalog structure for imaging biomarkers.
  • To improve standardization and interoperability of imaging biomarker data.

Main Methods:

  • Reviewed key resources like FDA-NIH BEST, QIBA, EMA, and scientific literature.
  • Extracted and consolidated attributes through expert consensus.
Keywords:
CatalogFAIRImaging biomarkerInteroperable

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Last Updated: Jun 10, 2026

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  • Organized variables into five domains aligned with FAIR principles.

    • Main Results:

    • Established a unified descriptor set across five domains: core identification, clinical context, technical information, validation, and administrative data.
    • Tested the catalog on diverse imaging biomarkers (ADC, FDG-PET, radiomics, Doppler ultrasound).
    • Demonstrated coherent descriptions, clarified roles, and promoted transparency and reproducibility.

    Conclusions:

    • Proposes a harmonized, scalable approach for cataloging imaging biomarkers.
    • Consistent descriptors facilitate integration into research, regulatory, and clinical workflows.
    • Enhances traceability, cross-disease comparability, and regulatory readiness.