B7x and myeloid-derived suppressor cells in the tumor microenvironment: A tale of two cities
Hyungjun Jeon1, Kim C Ohaegbulam, Yael M Abadi
1Department of Microbiology and Immunology; Albert Einstein College of Medicine; Bronx, NY USA.
Oncoimmunology
|September 28, 2013
Abstract:
A new study demonstrates the tumorigenic functions of B7x and reveals a link between B7x and myeloid-derived suppressor cells (MDSCs) within the tumor microenvironment. We propose that the binding of B7x to a hitherto unidentified receptor on MDSCs may stimulate their proliferation and/or immunosuppressive functions, hence promoting tumor growth.
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