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Updated: May 7, 2026
11:58
In-Nucleus Hi-C in Drosophila Cells
Published on: September 15, 2021
For genomes to stay in shape, insulators must be up to PAR
Patrick J Wijchers1, Wouter de Laat
1Hubrecht Institute-KNAW and University Medical Center Utrecht, Uppsalalaan 8, 3584 CT Utrecht, the Netherlands.
Cell
|October 1, 2013
Abstract:
Insulators drive nuclear organization by blocking or facilitating interactions between DNA regulatory elements. Ong et al. show that poly(ADP-ribosyl)ation of insulator binding proteins modulates their ability to physically interact with distant regulatory elements, implicating posttranslational modifications of nonhistone proteins in genome architecture.
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