Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Histone Modification

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

Genomic DNA in Eukaryotes

Genomic DNA in Eukaryotes

Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correcting spatial transcriptomics data affected by a prevalent transcript leakage problem across platforms, species, and tissues.

bioRxiv : the preprint server for biology·2026

Same author

A Coral-Inspired Dual Modal Hydrogel Sensor with Deep Learning-Assisted Decoupling of Force-Thermal Stimuli.

ACS applied materials & interfaces·2026

Same author

Multimodal PCSC Sensors for Real-Time Temperature and Force Detection Using LRTNet.

Sensors (Basel, Switzerland)·2026

Same author

Retroelement Hypomethylation Links Hypoxia Signaling, Immune Phenotypes, and Survival in Clear Cell Renal Cell Carcinoma.

bioRxiv : the preprint server for biology·2026

Same author

A Community Standard Multispecies Cell Atlas of the Basal Ganglia.

bioRxiv : the preprint server for biology·2026

Same author

Biogas production and microbial profile estimation in bioreactor landfills.

Frontiers in chemistry·2026

Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026

Same journal

Systematic discovery of pathogen effector functions across human pathogens and pathways.

Cell·2026

Same journal

Structural basis for host membrane binding and remodeling by invading malaria parasites.

Cell·2026

Same journal

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning.

Cell·2026

Same journal

Arc mediates intercellular tau transmission via extracellular vesicles.

Cell·2026

Same journal

Electromagnetic field-inducible in vivo gene switch for remote spatiotemporal control of gene expression.

Cell·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Mapping human epigenomes.

Chloe M Rivera¹, Bing Ren

¹Ludwig Institute for Cancer Research, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA; The Biomedical Sciences Graduate Program, Institute of Genomic Medicine, UCSD Moores Cancer Center, University of California School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0653, USA.

|October 1, 2013

Summary

This summary is machine-generated.

Epigenome maps reveal cell-specific information, aiding in the understanding of gene regulation and development. This review covers epigenome mapping tools and their applications in DNA methylation and chromatin structure analysis.

More Related Videos

Pattern-based Search of Epigenomic Data Using GeNemo

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

Related Experiment Videos

Last Updated: May 7, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Pattern-based Search of Epigenomic Data Using GeNemo

Pattern-based Search of Epigenomic Data Using GeNemo

Published on: October 8, 2017

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

A Semiautomated ChIP-Seq Procedure for Large-scale Epigenetic Studies

Published on: August 13, 2020

Area of Science:

Genomics and Epigenomics
Molecular Biology
Cell Biology

Background:

The epigenome, distinct from the genome, holds crucial cell-specific information.
Advancements in high-throughput technologies have enabled extensive human epigenome mapping.

Purpose of the Study:

To review the current epigenome mapping toolkit.
To discuss the utility of epigenome maps in understanding gene regulation and development.
To highlight progress and challenges in the field of epigenomics.

Main Methods:

Focus on mapping techniques for DNA methylation.
Analysis of chromatin modification states.
Characterization of chromatin structures.

Main Results:

Epigenome maps are instrumental in identifying human gene regulatory sequences.
These maps help delineate complex developmental programs.
Current tools provide insights into epigenetic variations across cell types.

Conclusions:

Epigenome mapping is a rapidly advancing field with significant implications for biology and medicine.
Further research is needed to overcome existing challenges and fully utilize epigenomic data.
Epigenome maps offer a powerful resource for deciphering cellular identity and function.