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Updated: May 7, 2026
05:11
Inkjet-printed Polyvinyl Alcohol Multilayers
Published on: May 11, 2017
Polyvinyl acetate-based film coatings.
K Kolter1, A Dashevsky, Muhamad Irfan
1BASF SE, Development Pharma Ingredients, Ludwigshafen, Germany.
International Journal of Pharmaceutics
|October 1, 2013
Summary
Polyvinyl acetate (Kollicoat® SR 30 D) offers pH-independent controlled drug release coatings. Its properties allow easy processing and adjustable drug release, presenting a novel alternative to OROS systems.
Area of Science:
- Pharmaceutical technology
- Materials science
Background:
- Kollicoat® SR 30 D is a polyvinyl acetate-based polymer dispersion used for controlled drug release coatings.
- It exhibits moderate swelling, lipophilicity, and pH-independent permeability, along with high flexibility.
- Its low minimum film forming temperature (MFT) of 18°C facilitates processing without plasticizers.
Purpose of the Study:
- To evaluate Kollicoat® SR 30 D for controlled release coating applications.
- To investigate the influence of formulation variables on drug release profiles.
- To explore its potential as an alternative to osmotic drug delivery systems.
Main Methods:
- Coating of pellets with Kollicoat® SR 30 D.
- Assessment of film properties including swelling, lipophilicity, and flexibility.
- Drug release studies under various conditions (pH, coating level, excipients).
- Evaluation of plasticizer and pore-former effects on film and release characteristics.
Main Results:
- Kollicoat® SR 30 D coatings demonstrated pH-independent drug release.
- Drug release was controllable via coating level and addition of pore-forming polymers (Kollidon® 30, Kollicoat® IR).
- Addition of triethyl citrate improved film flexibility and allowed for tablet compaction with minimal impact on drug release.
Conclusions:
- Kollicoat® SR 30 D is a versatile polymer for developing controlled-release dosage forms with pH-independent drug release.
- Formulation adjustments, including plasticizers and pore formers, effectively modulate drug release kinetics.
- Combinations with Kollicoat® IR offer a promising, drill-free alternative to OROS systems for controlled drug delivery.
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