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Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body being...
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET

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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space
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A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space

Published on: February 1, 2016

An animal PET scanner using flat-panel position-sensitive PMTs.

Takashi Okamoto, Kibou Ote, Koichi Sakai

    Annals of Nuclear Medicine
    |October 1, 2013
    PubMed
    Summary
    This summary is machine-generated.

    A new animal PET scanner using flat-panel position-sensitive photomultiplier tubes (PS-PMTs) was developed for non-human primates. This advanced imaging system demonstrates high resolution and sensitivity, aiding pre-clinical drug development.

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    A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging

    Published on: June 21, 2017

    Area of Science:

    • Medical Imaging
    • Nuclear Medicine
    • Biomedical Engineering

    Background:

    • Positron Emission Tomography (PET) is crucial for preclinical research.
    • Developing advanced PET scanners is essential for detailed in vivo imaging.
    • Non-human primates are vital models for human disease research.

    Purpose of the Study:

    • To design, construct, and validate a novel animal PET scanner.
    • To incorporate flat-panel position-sensitive photomultiplier tubes (PS-PMTs) for enhanced imaging.
    • To enable PET studies in conscious, non-human primates.

    Main Methods:

    • The scanner utilizes 30 detector modules with PS-PMTs and lutetium–yttrium oxyortho-silicate crystals.
    • A total of 17,280 crystals are arranged in 36 rings, with a 508 mm diameter.
    • A gantry tilt mechanism allows for imaging monkeys in a sitting position, with 2D/3D acquisition modes.

    Main Results:

    • Achieved high spatial resolution: 2.7 mm radial, 2.4 mm tangential, and 2.5 mm axial FWHM.
    • Demonstrated excellent system sensitivity: 1.3 kcps/(kBq/mL) in 2D and 7.4 kcps/(kBq/mL) in 3D mode.
    • Noise equivalent count rate in 3D mode matched 2D mode at higher radioactivity levels.

    Conclusions:

    • The developed PET scanner is a valuable research instrument for non-human primate studies.
    • It facilitates advanced pre-clinical drug development and evaluation.
    • The system's performance supports detailed in vivo investigations in primate models.