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Mirabegron for overactive bladder: a novel, first-in-class β3-agonist therapy
Mohammed Imran1, Abul Kalam Najmi, Shams Tabrez
1Department of Pharmacology, Hamdard Institue of Medical Sciences and Research and Associated Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi-110062, India. drimran@aol.in.
Urology Journal
|October 1, 2013
Summary
Mirabegron, a novel β3 receptor agonist, offers a promising treatment for overactive bladder (OAB) by relaxing the bladder muscle. This new approach avoids the side effects common with traditional antimuscarinic medications.
Area of Science:
- Pharmacology
- Urology
Background:
- Overactive bladder (OAB) is a common condition affecting bladder control.
- Current treatments for OAB often have associated side effects.
Purpose of the Study:
- To review the pharmacotherapeutic properties of Mirabegron.
- Mirabegron is a novel β3 receptor agonist approved for OAB treatment.
Main Methods:
- Computerized literature search of MEDLINE/PUBMED.
- Keywords: Mirabegron, β3 receptor agonist, overactive bladder.
Main Results:
- Mirabegron activates β3 adrenergic receptors, increasing intracellular cAMP and Ca2+.
- This leads to nitric oxide (NO) release, relaxing the detrusor muscle.
- It also releases urothelial-derived inhibiting factor (UDIF), inhibiting contractions and increasing bladder capacity.
Conclusions:
- Mirabegron represents a promising therapeutic option for OAB.
- It shifts OAB management towards bladder relaxation.
- Mirabegron offers an alternative with fewer side effects than antimuscarinic drugs.
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