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Increased aortic stiffness predicts contrast-induced nephropathy in patients with stable coronary artery disease

Hakan Uçar1, Mustafa Gür2, Arafat Yildirim2

  • 1Department of Cardiology, Adana Numune Training and Research Hospital, Adana, Turkey ucarhakan2005@gmail.com.

Angiology
|October 1, 2013
PubMed

Insights

Increased aortic stiffness, a measure of arterial health, may predict contrast-induced nephropathy (CIN) in patients with coronary artery disease undergoing procedures. Higher pulse wave velocity (PWV) indicates greater risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Vascular Medicine

Background:

  • Aortic stiffness (AS) is a risk factor for cardiovascular disease, particularly in renal insufficiency.
  • AS is linked to mild renal impairment and may be relevant in patients undergoing procedures requiring contrast media.

Purpose of the Study:

  • To investigate the relationship between aortic stiffness parameters and contrast-induced nephropathy (CIN).
  • To identify predictors of CIN in patients with stable coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI).

Main Methods:

  • Prospective study of 440 patients with stable CAD undergoing PCI.
  • Aortic stiffness parameters, including pulse wave velocity (PWV) and augmentation index (AIx), were measured using the single-point method.
  • Predictors for CIN were analyzed using logistic regression and receiver-operator characteristic (ROC) curve analysis.

Main Results:

  • Pulse wave velocity (PWV), age, diabetes, SYNTAX score, and contrast media dose were independent predictors of CIN (P < .05).
  • A PWV cutoff value of 10.35 m/s predicted CIN with 82.1% sensitivity and 77.9% specificity (P < .001).
  • Higher AS pre-PCI was associated with an increased likelihood of developing CIN.

Conclusions:

  • Increased aortic stiffness, specifically higher PWV, may predict the development of CIN in patients with stable CAD undergoing PCI.
  • Aortic stiffness assessment could aid in identifying patients at higher risk for CIN.
  • This finding highlights the interplay between vascular health and kidney function in the context of contrast procedures.

Keywords:
PCIaortic stiffnesscontrast-induced nephropathycoronarypulse wave velocity

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