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Updated: May 7, 2026

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles
Published on: March 15, 2012
Two new compounds from gorgonian-associated fungus Aspergillus sp
Xin-Ya Xu1, Xiao-Yong Zhang, Fei He
1Key Laboratory of Marine Bio-resources Sustainable Utilization/Guangdong Key Laboratory of Marine Material Medical, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, PR China.
Abstract:
One new gamma-lactone derivative 5-hydroxy-3-isopropyl-4-methoxyfuranone (1) and one new lactam derivative dehydrated-marinamide (2), along with two known compounds marinamide (3) and marinamide methyl ester (4) were isolated from the fermentation broth of the marine gorgonian-associated fungus Aspergillus sp. SCSGAF0093. Their structures were elucidated on the basis of spectroscopic and spectrometric analysis. Compound 1 showed significant toxicity to brine shrimp (Artemia salina) with a median lethal concentration (LC50) of 1.25 microM, and 3 inhibited protein tyrosine phosphatase 1B (PTP1B) with a half maximal inhibitory concentration (IC50) of 23.3 microg/mL.
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