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Flavonoids with anti-HSV activity from the root bark of Artocarpus lakoocha
Boonchoo Sritularak1, Kullasap Tantrakarnsakul, Vimolmas Lipipun
1Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand. Boonchoo.Sr@chula.ac.th
Abstract:
From the MeOH extract of the root bark of Artocarpus lakoocha, a new compound 5,7,2',4'-tetrahydroxy-6-geranyl-3-prenyl-flavone (1) was isolated, along with three known flavonoids (+)-afzelechin-3-O-alpha-L-rhamnopyranoside (2), (+)-catechin (3) and cudraflavone C (4). Evaluation of these isolates for inhibitory effects against Herpes simplex virus (HSV) types 1 and 2 was carried out using the inactivation method. Compounds 1 and 4 showed moderate and weak activity against both types of HSV, respectively, whereas 2 and 3 were devoid of activity.
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