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Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...

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Related Experiment Video

Updated: May 7, 2026

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
11:07

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

Endoscopic therapy for chronic pancreatitis.

Jean-Marc Dumonceau1

  • 1Division of Gastroenterology and Hepatology, Geneva University Hospitals, Rue Gabrielle Perret Gentil 4, Geneva 1211, Switzerland.

Gastrointestinal Endoscopy Clinics of North America
|October 2, 2013
PubMed
Summary
This summary is machine-generated.

Endoscopic therapy is the primary treatment for painful chronic pancreatitis with main pancreatic duct (MPD) obstruction. Management involves addressing stones with lithotripsy and strictures with stenting, with regular stent exchange recommended.

Keywords:
Celiac plexus blockChronic pancreatitisEndoscopic retrograde cholangio-pancreatographyEndoscopic ultrasonographyExtracorporeal shockwave lithotripsyGuidelinePainTreatment

Related Experiment Videos

Last Updated: May 7, 2026

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
11:07

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

Area of Science:

  • Gastroenterology and Endoscopy
  • Pancreatic Diseases
  • Minimally Invasive Therapies

Background:

  • Chronic pancreatitis often causes significant pain due to main pancreatic duct (MPD) obstruction.
  • Endoscopic interventions are increasingly utilized for managing complications of chronic pancreatitis.
  • Obstructions can be caused by calcified stones or dominant strictures, necessitating specific therapeutic approaches.

Purpose of the Study:

  • To outline the recommended endoscopic therapeutic strategies for painful chronic pancreatitis with MPD obstruction.
  • To detail the management of pancreatic stones and strictures within the MPD.
  • To provide guidelines for the treatment and follow-up of pancreatic pseudocysts amenable to endoscopic therapy.

Main Methods:

  • Extracorporeal shockwave lithotripsy (ESWL) for calcified MPD stones.
  • Endoscopic stenting with large plastic stents for dominant MPD strictures, with recommended exchange intervals.
  • Endoscopic management of pancreatic pseudocysts within reach.

Main Results:

  • Clinical response to endoscopic therapy should be assessed 6-8 weeks post-intervention.
  • ESWL is the initial treatment for obstructive calcified stones in the MPD.
  • Optimal management of dominant MPD strictures involves a single large plastic stent, requiring exchange within one year, irrespective of symptoms.

Conclusions:

  • Endoscopic therapy is the recommended first-line treatment for painful chronic pancreatitis with MPD obstruction.
  • A structured approach involving ESWL, stenting, and timely stent exchange is effective for MPD stone and stricture management.
  • Endoscopic treatment is a viable option for indicated pancreatic pseudocysts within endoscopic reach.