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Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Cancer-Critical Genes I: Proto-oncogenes01:33

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Related Experiment Video

Updated: May 7, 2026

Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies
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Cancer-Associated Fibroblasts from Mouse Mammary Tumors as Tools for Molecular and Computational Studies

Published on: July 3, 2025

IGF2 and cancer.

Callum Livingstone1

  • 1Peptide Hormones Supraregional Assay Service (SAS), Clinical Biochemistry Department, Royal Surrey County Hospital NHS Trust, Guildford, Surrey GU2 7XX, UK Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 5XH, UK.

Endocrine-Related Cancer
|October 2, 2013
PubMed
Summary
This summary is machine-generated.

Insulin-like growth factor 2 (IGF2) is a key hormone implicated in cancer development and prognosis. Measuring IGF2 levels and analyzing its gene may offer new ways to assess cancer risk and guide treatment.

Keywords:
IGF2cancernon-islet cell tumour hypoglycaemia

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Area of Science:

  • Endocrinology
  • Molecular Biology
  • Oncology

Background:

  • Insulin-like growth factor 2 (IGF2) is a highly abundant mitogenic hormone with poorly understood roles compared to IGF1.
  • IGF2 gene over-expression is linked to various cancers and poor prognosis.
  • Elevated serum IGF2 correlates with increased cancer risk.

Purpose of the Study:

  • To review the clinical significance of IGF2 in cancer.
  • To explore novel diagnostic and prognostic applications of IGF2 measurement.
  • To discuss emerging therapeutic strategies targeting IGF2.

Main Methods:

  • Literature review of recent research on IGF2 in cancer.
  • Analysis of clinical utility of IGF2 measurement.
  • Examination of genetic and epigenetic factors influencing IGF2.

Main Results:

  • IGF2 measurement is clinically useful for diagnosing non-islet cell tumour hypoglycemia.
  • IGF2 over-expression is a biomarker for poor cancer prognosis.
  • Blood tests and genetic analyses of IGF2 show potential for cancer risk assessment.

Conclusions:

  • IGF2 plays a significant role in cancer pathophysiology.
  • IGF2 measurement and genetic testing offer promising avenues for cancer management.
  • Further research is needed to integrate these findings into clinical practice.