Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Drug Dissolution: Requirements and Profile Comparison

The acceptance criteria for dissolution profile data are anchored in Q values, representing the percentage of drug dissolved within a specified period. This assessment unfolds in three stages:First Stage: The test passes if all six drug dosage units are equal to or greater than Q plus 5%; otherwise, the sample proceeds to the second stage.Second Stage: The average of twelve units must be equal to or greater than Q, with no unit falling below Q - 15% to pass; if not, it progresses to the final...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hippocampal subfield volumes and associated cognitive decline with ageing.

Brain research·2026

Same author

Age-related cortical changes and cognitive performance in healthy adults.

Brain and cognition·2025

Same author

Enhancement of Cellulase Activity from a New Strain of Bacillus subtilis by Medium Optimization and Analysis with Various Cellulosic Substrates.

Enzyme research·2011

Same author

Nimesulide and beta-cyclodextrin inclusion complexes: physicochemical characterization and dissolution rate studies.

Drug development and industrial pharmacy·2000

Search research articles

Related Experiment Video

Updated: May 7, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive ¹⁹F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

Stability-indicating Method for the Estimation of Riluzole in Tablets.

T Neeha¹, P Bhargavi, A Aruna Jyothi

¹Department of Pharmaceutical Analysis, K. V. S. R. Siddhartha College of Pharmaceutical Sciences, Pinnamaneni Polyclinic Road, Siddhartha Nagar, Benz Circle, Vijayawada-520 010, India.

Indian Journal of Pharmaceutical Sciences

|October 2, 2013

Summary

A new stability-indicating method accurately measures riluzole in bulk and tablets. This high-pressure liquid chromatography method is validated and effective for quality control of riluzole formulations.

Keywords:

Riluzole forced degradation reverse phase liquid chromatography validation

More Related Videos

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Related Experiment Videos

Last Updated: May 7, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive ¹⁹F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

Formation of Dispersible Taohong Siwu Tablets

Formation of Dispersible Taohong Siwu Tablets

Published on: February 3, 2023

Area of Science:

Analytical Chemistry
Pharmaceutical Analysis

Background:

Riluzole is a medication used to treat amyotrophic lateral sclerosis (ALS).
Ensuring the stability and accurate quantification of riluzole in pharmaceutical formulations is crucial for patient safety and therapeutic efficacy.

Purpose of the Study:

To develop and validate a stability-indicating analytical method for the estimation of riluzole.
To assess the degradation behavior of riluzole under various stress conditions.

Main Methods:

A stability-indicating reverse-phase high-performance liquid chromatography (RP-HPLC) method was developed using a photodiode array (PDA) detector.
Riluzole samples (bulk and tablet dosage forms) were subjected to stress conditions including light, heat, humidity, acid/base hydrolysis, and oxidation.
The developed method was validated according to International Conference on Harmonization (ICH) guidelines.

Main Results:

The method demonstrated good resolution between riluzole and its degradation products.
Degradation of riluzole was observed under acidic, basic, oxidative, and thermal stress conditions.
The method showed linearity in the range of 10-50 μg/ml with a correlation coefficient of 0.9998, indicating high precision and accuracy (assay 100.92%, recovery 101.10%).

Conclusions:

The developed RP-HPLC-PDA method is stability-indicating, specific, and suitable for the quantitative analysis of riluzole in bulk and pharmaceutical formulations.
The method provides a reliable tool for quality control and stability assessment of riluzole products.