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Anticholinesterase Agents: Poisoning and Treatment01:26

Anticholinesterase Agents: Poisoning and Treatment

Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.     
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Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...
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Drug Toxicity: Dose-Dependent Reactions

Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
Toxidromes: Clinical Features01:30

Toxidromes: Clinical Features

Toxidromes are specific patterns of symptoms resulting from toxic substance exposure. They help in the identification and treatment of poisoning. The symptoms of each toxidrome group indicate poisoning by a certain class of chemicals or drugs.1. Sympathomimetic: Stimulates the sympathetic nervous system. Symptoms include agitation, increased heart rate (HR), blood pressure (BP), respiratory rate (RR), temperature, and pupil size. Drugs like cocaine and amphetamines, along with tremors and...
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Liddle syndrome is a genetically inherited form of hypertension characterized by the overactivity of epithelial sodium channels in the nephron, the functional unit of the kidney. This heightened activity leads to increased sodium reabsorption and excessive excretion of potassium. To counteract this, potassium-sparing diuretics such as amiloride are used. They function by blocking these sodium channels, thereby reducing the influx of sodium into the epithelial cells and minimizing the loss of...
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Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
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Published on: February 3, 2021

Amlodipine overdose.

Tapan Patel1, David Tietze, Ankit N Mehta

  • 1Department of Nephrology, Texas Health Presbyterian Hospital, Dallas, Texas (Patel); the Department of Sports Medicine, Ohio State University, Columbus, Ohio (Tietze); the Division of Nephrology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas (Mehta); and the Department of Internal Medicine, Texas A&M Health Science Center, College of Medicine (Mehta).

Proceedings (Baylor University. Medical Center)
|October 2, 2013
PubMed
Summary
This summary is machine-generated.

A young woman intentionally overdosed on amlodipine, simvastatin, and trazodone. This case highlights the critical need for prompt medical evaluation following significant intentional drug ingestion.

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Last Updated: May 7, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders
05:58

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Published on: February 3, 2021

Area of Science:

  • Cardiology
  • Clinical Pharmacology
  • Toxicology

Background:

  • Intentional drug overdose presents a significant public health challenge.
  • Amlodipine, simvastatin, and trazodone are commonly prescribed medications with distinct pharmacological profiles.

Purpose of the Study:

  • To report a case of intentional co-ingestion of amlodipine, simvastatin, and trazodone.
  • To discuss the potential toxicological implications and clinical management of such an overdose.

Main Methods:

  • Case report detailing a 24-year-old female patient.
  • Review of the patient's medical history and circumstances of ingestion.
  • Clinical assessment and management strategies employed.

Main Results:

  • The patient intentionally ingested a substantial quantity of amlodipine (400-600 mg) along with numerous simvastatin and trazodone tablets.
  • Clinical presentation and laboratory findings were monitored closely.

Conclusions:

  • Intentional overdose of multiple medications requires careful clinical monitoring and management.
  • Understanding the combined effects of amlodipine, simvastatin, and trazodone in overdose is crucial for patient care.