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Related Concept Videos

Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Ovarian Cycle01:27

Ovarian Cycle

The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
Oogenesis01:22

Oogenesis

Oogenesis,  the process of developing egg cells (female gametes), occurs within the ovaries and is fundamental to female fertility. This sequence begins during fetal development when diploid oogonia in the developing ovaries undergo mitotic divisions to produce primary oocytes. By birth, these primary oocytes enter prophase I of meiosis but become arrested in this stage, remaining suspended until puberty.
Each primary oocyte is surrounded by a layer of pre-granulosa cells, forming what is known...
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of endometrial...

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Updated: May 7, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Current evidence supporting "letrozole" for ovulation induction.

Sujata Kar1

  • 1Department of Obstetrics and Gynecology, Kar Clinic and Hospital Pvt. Ltd, Bhubaneswar, Odisha, India.

Journal of Human Reproductive Sciences
|October 2, 2013
PubMed
Summary
This summary is machine-generated.

Letrozole is a promising oral medication for ovulation induction (OI) in women with PCOS and CC resistance. While effective, its long-term safety and efficacy for OI require further investigation.

Keywords:
Aromatase inhibitorcongenital malformationsletrozoleovulation induction

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A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
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Last Updated: May 7, 2026

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
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Published on: September 16, 2021

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
04:49

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Published on: July 5, 2024

Area of Science:

  • Reproductive endocrinology
  • Pharmacology

Background:

  • Letrozole, an aromatase inhibitor, has emerged as a potential ovulation induction (OI) agent.
  • Extensive research has explored its use in various gynecological conditions, including polycystic ovary syndrome (PCOS) and clomiphene citrate (CC) resistance.

Purpose of the Study:

  • To review current scientific data on the efficacy and safety of letrozole for ovulation induction (OI).

Main Methods:

  • Literature review of published studies on letrozole for OI.
  • Analysis of data regarding letrozole's use in PCOS, CC-resistant women, IUI, and IVF/ICSI protocols.

Main Results:

  • Letrozole offers advantages such as oral administration, cost-effectiveness, a short half-life, and minimal side effects.
  • Its application in OI has been investigated across diverse patient populations and treatment protocols.

Conclusions:

  • Letrozole presents a viable option for OI due to its favorable characteristics.
  • Further research is needed to definitively establish the long-term efficacy and safety of letrozole for ovulation induction.