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Related Concept Videos

Hazard Ratio01:12

Hazard Ratio

The hazard ratio (HR) is a widely used measure in clinical trials to compare the risk of events, such as death or disease recurrence, between two groups over time. It reflects the ratio of hazard rates—the instantaneous risk of the event occurring—between a treatment group and a control group. This measure provides valuable insights into the relative effectiveness of a treatment by assessing how the risk of an event differs between the two groups.
For example, in a clinical trial evaluating a...
Regulation of the Unfolded Protein Response01:31

Regulation of the Unfolded Protein Response

Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
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Assembly of the Lipid Bilayer in the ER01:28

Assembly of the Lipid Bilayer in the ER

Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
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RL Circuits01:14

RL Circuits

An RL circuit consists of a resistor and an inductor and may have a source of emf connected to it. The inductor in the circuit helps to prevent rapid changes in current, which can be helpful if a steady current is required but the external source has a fluctuating emf. Consider an open RL circuit connected to a source of constant emf. As soon as the circuit is closed, the current begins to increase at a rate that depends only on the value of the inductance in the circuit. The greater the...

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Related Experiment Video

Updated: May 7, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Resilon: a comprehensive literature review.

Mehrdad Lotfi1, Negin Ghasemi, Saeed Rahimi

  • 1Professor, Department of Endodontic, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Journal of Dental Research, Dental Clinics, Dental Prospects
|October 2, 2013
PubMed
Summary

Resilon, a root canal filling material, demonstrates good sealing and biocompatibility. However, further clinical research is necessary to confirm its long-term efficacy compared to other dental materials.

Keywords:
Antibacterial activityResilonchemical and physical propertiesclinical outcomecytotoxicitydisinfectionleakageretreatment

Related Experiment Videos

Last Updated: May 7, 2026

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time
06:05

The Participant-Reported Implementation Update and Score (PRIUS): A Novel Method for Capturing Implementation-Related Data Over Time

Published on: February 19, 2021

Area of Science:

  • Endodontics
  • Dental Materials Science

Background:

  • Ideal root canal filling materials require complete sealing, biocompatibility, and dimensional stability.
  • Dentin bonding is a desirable property to prevent leakage and enhance sealing.
  • Resilon was developed to address the lack of dentin bonding in existing root canal filling materials.

Purpose of the Study:

  • To review and present investigations on Resilon's physical and chemical properties.
  • To evaluate leakage studies associated with Resilon.
  • To assess Resilon's potential as a root canal filling material.

Main Methods:

  • A comprehensive literature review was conducted.
  • Electronic and hand searching methods were employed for Resilon.
  • The search covered publications from May 2004 to April 2012.

Main Results:

  • Resilon is composed of polycaprolactone and filler particles, exhibiting antibacterial and antifungal properties.
  • It shows promise as a root canal filling material with good sealing and biocompatibility.
  • Drawbacks include high cost, and limited clinical research despite numerous case reports.

Conclusions:

  • Resilon offers effective sealing and biocompatibility for root canal therapy.
  • Further well-designed clinical studies are essential to validate its efficacy against alternative materials.