Cell-mediated immune response in rubella infections

Cultures of lymphocytes from rubella-susceptible persons did not respond to stimulation with purified rubella antigen whereas those from persons who had experienced natural infection responded strongly to specific antigenic stimulation. The response of cultures of lymphocytes from vaccinees is weaker than that of naturally infected persons, and it appears that the response of lymphocytes from congenitally infected children depends on their gestational age at the time of interuterine infection. Vaccination or revaccination of immune subjects elicits a fast booster-type cell-mediated immune response. This property is useful for detecting the immune status of women exposed to rubella during pregnancy whose rubella history is unknown and whose humoral immune response is negative.