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Related Experiment Video

Updated: May 7, 2026

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Inactivation of Pathogens via Visible-Light Photolysis of Riboflavin-5′-Phosphate

Published on: April 6, 2022

Modified-release capsules containing sodium riboflavin 5'-phosphate.

Gyula Buchholcz¹, András Kelemen, Klára Pintye-Hódi

¹Bajai Szent Rókus Hospital , Baja , Hungary .

Drug Development and Industrial Pharmacy

|October 3, 2013

Summary

Delayed-release capsules containing riboflavin (vitamin B2) layered pellets were developed. The study optimized coating thickness to control riboflavin dissolution and enhance bioavailability.

Keywords:

Dissolution fitting hard capsule coating layering technique theoretical model

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Published on: August 22, 2017

Area of Science:

Pharmaceutical Sciences
Drug Delivery Systems
Nutritional Biochemistry

Background:

Riboflavin (vitamin B2) deficiency can arise from malabsorption, alcoholism, or protein-calorie deficits.
Riboflavin is absorbed in the upper gastrointestinal tract via a specific transport mechanism.
Controlled dissolution is crucial for effective riboflavin therapy.

Purpose of the Study:

To develop delayed-release capsules with optimized riboflavin (vitamin B2) layered pellets.
To control the dissolution rate and enhance the bioavailability of riboflavin.
To predict the optimal coating thickness for desired drug release.

Main Methods:

Layering of sodium riboflavin 5'-phosphate onto core pellets (Cellet 300).
Coating of riboflavin-loaded pellets with Eudragit NE polymer at varying thicknesses.
Dissolution testing in simulated gastric and intestinal fluids using the half-change method.
Analysis of dissolution profiles using mathematical models (RRSBW, Chapman-Richards).

Main Results:

A novel solid dosage form for enhanced riboflavin bioavailability was successfully developed.
Dissolution profiles were best described by the Chapman-Richards growth function.
A theoretical model was established for predicting optimal film thickness for riboflavin release.

Conclusions:

The developed delayed-release capsules offer a promising approach for improving riboflavin bioavailability.
Mathematical modeling provides a predictive tool for optimizing drug release characteristics.
Coating thickness is a critical factor in controlling the dissolution of riboflavin layered pellets.