Related Experiment Video
Updated: May 7, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
Recent advances in the use of cyclodextrins in antifungal formulations
Fliur Macaev1, Veaceslav Boldescu, Athina Geronikaki
1Institute of Chemistry, Academy str. 3, MD-2028, Chisinau, Moldova. flmacaev@cc.acad.md.
Abstract:
Cyclodextrins are usually used in antifungal formulations as auxiliary substances to improve solubility, stability, or other physicochemical properties of the active compound. Nevertheless, more and more research and practical use results indicate that cyclodextrins might also act as active compounds in pharmaceutical formulations. The biological effects of cyclodextrins, important for their use within antimycotic formulations, can be divided into: effects based on the ability of cyclodextrins to form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), effects based on formation of inclusion complexes with component parts of fungi cells, and effects based on the chemical nature of cyclodextrins and their derivatives. This review will cover the advances in research of biological activity of cyclodextrins with focus on their properties responsible for their synergistic effect with antimycotic compounds.
More Related Videos
Related Concept Videos
Antifungal Agents
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Oral Drug Delivery Systems: Continuous-Release Systems
Oral Drug Delivery Systems: Introduction
Site-Targeted Drug Delivery Systems: Polymeric Carriers
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions

