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Updated: May 7, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
An update on oxidative stress-mediated organ pathophysiology
Kahkashan Rashid1, Krishnendu Sinha, Parames C Sil
1Division of Molecular Medicine, Bose Institute, P-1/12, CIT Scheme VII M, Calcutta 700054, West Bengal, India.
Environmental pollutants and drugs cause organ damage. This review explores how natural compounds combat oxidative stress, aiding cellular survival and offering therapeutic potential.
Area of Science:
- Biochemistry
- Toxicology
- Pharmacology
Background:
- Environmental pollutants and drugs can induce harmful pathophysiological changes.
- Understanding cellular survival and death mechanisms is crucial for developing therapeutic strategies.
- Naturally occurring bioactive molecules offer potential therapeutic benefits with minimal side effects.
Purpose of the Study:
- To detail the mechanisms of oxidative stress-mediated organ pathophysiology.
- To elucidate the cellular fate (survival, necrosis, apoptosis) under stress.
- To review the beneficial roles of natural bioactive molecules in mitigating oxidative stress-induced organ damage.
Main Methods:
- Literature review of oxidative stress mechanisms.
- Analysis of cellular death pathways (necrosis and apoptosis).
- Investigation of natural bioactive molecules' effects on oxidative stress.
Main Results:
- Detailed mechanisms of organ pathophysiology induced by oxidative stress are described.
- The complex interplay between various pathways in stressed conditions is highlighted.
- Beneficial effects of several natural bioactive molecules on oxidative stress-mediated pathophysiology are presented.
Conclusions:
- Oxidative stress significantly impacts organ pathophysiology and cellular fate.
- Naturally occurring bioactive molecules show promise in therapeutic applications for oxidative stress-related conditions.
- Further research into these molecules could lead to novel treatment strategies.
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