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Updated: May 7, 2026

Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
Published on: December 15, 2023
Quality of life, depression, and anxiety among hepatitis B patients
Gülseren Keskin1, Aysun Babacan Gümüs, Fatma Orgun
1About the authors: Gülseren Keskin, PhD, is Associate Professor, Psychiatric Nursing Department, Ege University, Atatürk Medical Technology Vocational Training School, Bornova, Izmir, Turkey. Aysun Babacan Gümüs¸, PhD, is Associate Professor, Psychiatric Nursing Department, Çanakkale Onsekiz Mart University, School of Health, Çanakkale, Turkey. Fatma Orgun, PhD, is Assistant Professor, Ege University Nursing High School, Bornova, Izmir, Turkey.
Abstract:
This descriptive cross-sectional study was designed to determine the depression and anxiety levels, and their effects, on quality of life of patients with chronic Hepatitis B. Chronic infection with Hepatitis B virus has a profound effect on health-related quality of life. Medications, including interferon, that are commonly used to treat chronic viral Hepatitis B may cause depression as an adverse effect. However, little is known about the impact of depression and anxiety on quality of life in patients with Hepatitis B. A total of 96 patients aged between 15 and 61 years were included in the study. Slightly more than half of them (52%) were female. Three scales-the Beck Depression Inventory, Beck Anxiety Scale, and Short Form of the World Health Organization Quality of Life Questionnaire (WHOQOL-BREF)-were used in the study. The scores obtained from the BDS in 91.7% of the patients were above the cutoff value of 17. Moreover, 80 patients received interferon. There was a negative correlation between the physical, environmental, and cultural areas on the Beck Anxiety Scale and WHOQOL-BREF (Turkish) (p< .05). A high level of depressive symptoms was established in this study, and the physical, environmental, and cultural aspects of quality of life were determined to increase as the anxiety level increased.
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