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Updated: May 7, 2026
06:01
A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Migraine and hemorrhagic stroke: a meta-analysis
Simona Sacco1, Raffaele Ornello, Patrizia Ripa
1From the Department of Neurology, University of L'Aquila, Italy.
Stroke
|October 3, 2013
Summary
Migraine sufferers face an increased risk of hemorrhagic stroke, particularly women under 45. This meta-analysis confirms a significant association, highlighting the need for further research into specific risk factors.
Area of Science:
- Neurology
- Epidemiology
- Public Health
Background:
- Migraine is a common neurological disorder.
- Previous studies on migraine and hemorrhagic stroke risk have yielded conflicting results.
- No comprehensive meta-analysis has been conducted on this topic.
Purpose of the Study:
- To systematically evaluate the association between migraine and the risk of hemorrhagic stroke.
- To pool data from existing studies to provide a more robust estimate of risk.
Main Methods:
- A systematic literature search was performed across multiple electronic databases (MEDLINE, EMBASE, Science Citation Index, Cochrane Library) up to March 2013.
- Case-control and cohort studies with clear diagnostic criteria and adjusted analyses for confounders were selected.
- Pooled adjusted odds ratios and hazard ratios were calculated to estimate the effect size.
Main Results:
- Eight studies involving 1600 hemorrhagic strokes were included in the meta-analysis.
- Overall, individuals with any migraine showed a 1.48-fold increased risk of hemorrhagic stroke (95% CI, 1.16-1.88; P=0.002).
- The risk was significantly higher in females with any migraine (1.55-fold) and in female migraineurs under 45 years old (1.57-fold).
Conclusions:
- The findings suggest a statistically significant increased risk of hemorrhagic stroke in individuals with migraine.
- Further research is warranted to explore risks based on migraine subtype, age, sex, and specific types of hemorrhagic stroke.
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