Vitreous hemorrhage secondary to presumed ocular histoplasmosis syndrome

Hemorrhagic retinal pigment epithelium detachment caused by choroidal neovascular membrane progressed to massive vitreous hemorrhage in two patients with presumed ocular histoplasmosis syndrome. When the hemorrhage cleared, a diskiform mass became visible. In one patient, this was located near the midnasal periphery. In endemic areas of histoplasmosis, presumed ocular histoplasmosis syndrome should be considered as a possible cause of spontaneous vitreous hemorrhage.