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Updated: May 7, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Polymorphisms in the endothelial nitric oxide synthase gene associated with recurrent miscarriage
1Department of Forensic Science, School of Medicine, Xi'an Jiaotong University/Key Laboratory of Ministry of Public Health for Forensic Science, Xi'an, Shaanxi, China.
Genetics and Molecular Research : GMR
|October 3, 2013
Summary
Genetic variations in the endothelial nitric oxide synthase (eNOS) gene are linked to recurrent miscarriage (RM). Specific eNOS gene polymorphisms, rs1799983 and rs11771443, show significant associations with RM susceptibility in the Chinese Han population.
Area of Science:
- Genetics
- Reproductive Biology
- Molecular Biology
Background:
- Endothelial nitric oxide synthase (eNOS) plays a role in pregnancy maintenance.
- Previous research on eNOS gene polymorphisms and recurrent miscarriage (RM) has yielded controversial results.
- Identifying genetic factors contributing to RM is crucial for understanding pregnancy loss.
Purpose of the Study:
- To investigate the association between specific single nucleotide polymorphisms (SNPs) of the eNOS gene and recurrent miscarriage (RM).
- To identify potential genetic markers for RM susceptibility in the Chinese Han population.
Main Methods:
- Genotyping of 8 eNOS gene SNPs (rs1799983, rs2070744, rs11771443, rs3918188, rs2853796, rs7830, rs1541861, rs2853792) using the MassARRAY system.
- Case-control study involving 192 RM patients and 201 fertile controls.
- Analysis of genotype and allele frequencies, linkage disequilibrium, and haplotype associations.
Main Results:
- Significant association found between rs1799983 polymorphism and RM (genotype P=0.001, allele P=0.016).
- Significant association observed for rs11771443 polymorphism with RM (genotype P=0.044, allele P=0.008).
- T-T-G haplotype in block 1 showed significantly lower frequency in RM patients (P=0.015), indicating linkage disequilibrium.
Conclusions:
- eNOS gene polymorphisms, specifically rs1799983 and rs11771443, are associated with recurrent miscarriage in the Chinese Han population.
- These findings contribute to understanding the genetic basis of RM.
- The study may inform future research on the genetic and neurobiological aspects of recurrent miscarriage.
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