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Published on: February 12, 2017
Small-cell lung cancer exhibiting spontaneous regression
Shin-ichiro Iwakami1, Mitsuhiro Fujii, Toshiji Ishiwata
1Department of Respiratory Medicine, Juntendo University Shizuoka Hospital, Japan.
Internal Medicine (Tokyo, Japan)
|October 4, 2013
Summary
A woman
Area of Science:
- Oncology
- Immunology
Background:
- A 56-year-old woman presented with persistent cough and weight loss.
- Imaging revealed a middle mediastinal tumor, initially heterogeneous.
Observation:
- The mediastinal tumor unexpectedly decreased in size before biopsy.
- Video-assisted thoracoscopic biopsy was performed for diagnosis.
Findings:
- Pathology confirmed small-cell lung cancer with CD8-positive T-cell infiltration.
- The tumor demonstrated signs of spontaneous regression.
Implications:
- CD8-positive T-cells and cell-mediated immunity may play a role in spontaneous tumor regression.
- This case highlights potential immune system involvement in fighting cancer.
