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Updated: May 7, 2026

A Murine Model of Hemodialysis Access-Related Hand Dysfunction
Published on: May 31, 2022
Multidisciplinary approach to hemodialysis graft dysfunction and thrombosis
Insights
A multidisciplinary protocol effectively maintains arteriovenous hemodialysis graft (AVG) patency, reducing the need for central venous catheters and hospital admissions. This approach ensures good AVG permeability and function for patients undergoing hemodialysis.
Area of Science:
- Vascular Surgery
- Nephrology
- Interventional Radiology
Background:
- Arteriovenous grafts (AVGs) are crucial for hemodialysis access.
- Maintaining AVG patency is essential for effective treatment.
- AVG dysfunction and thrombosis can lead to significant complications.
Purpose of the Study:
- To analyze the clinical outcomes of a multidisciplinary protocol for maintaining AVG patency.
- To evaluate the effectiveness of the protocol in managing AVG dysfunction and thrombosis.
Main Methods:
- Prospective recording of interventions for AVG dysfunction from 1999-2007.
- Treatment of AVG stenosis via percutaneous angioplasty (PA).
- Treatment of AVG thromboses with surgical thrombectomy and PTFE bridges when necessary.
Main Results:
- 96 AVG dysfunctions were analyzed, primarily PTFE grafts.
- High rates of interventions including PA, thrombectomies, and PTFE bridges were performed.
- Primary patency rates were 73.68% at 1 year, decreasing to 37.52% at 3 years.
- Secondary patency rates were 89.49% at 1 year, decreasing to 66.84% at 3 years.
- Central venous catheter use was avoided in 80% of thrombosis interventions.
- No procedure-related deaths occurred, with low hospital admission rates.
Conclusions:
- A combined protocol for AVG dysfunction and thrombosis, following DOQI recommendations, yields good results.
- The protocol effectively maintains AVG patency and function.
- This multidisciplinary approach improves outcomes for hemodialysis patients with AVG access.
Purpose:
Top analize the clinic results of the implantation of a multidisciplinary protocol to maintain permeability of the arteriovenous hemodialysis grafts (AVG).
Method:
Prospective recording of all interventions (radiological and surgical) on AVG dysfunction in the 1999-2007 period. The AVG stenosis were always treated by percutaneous angioplasty (PA) except stenosis recurrence in less than three months or persistence after PA. The AVG thromboses were always treated by surgical thrombectomy plus PTFE bridge if necessary. Complications, primary and secondary AVG patency were reviewed.
Results:
Ninety six dysfunction AVG were collected for study. All of them were 6x40 mm standard wall PTFE (Gore-Tex®). Thirty six of them were humero-basilic antebraquial loop and sixty were humero-axillary upper arm curve configuration. During the study, 52 PTFE bridges, 109 surgical thrombectomies, 131 PA, and 15 stents were needed to maintain FAVP permeability. Primay patency was 73.68%, 60.21% and 37.52% at one, two and three years respectively. Secondary patency was 89.49%, 84.07% and 66.84% at one, two and three years respectively. We avoid a central venous catheter (CVC) in the 80% of intervention for thrombosis dysfunction. No surgical or radiological related deaths occurred. Median hospital admission related with AVG thrombosis was 0.03/patient/year.
Conclusion:
The application of a combined protocol for the treatment of AVG dysfunction and thrombosis, according to DOQI recomendations obtains good results in AVG patency in our experience.
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