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Hyperglycemia and mortality among patients with coronary artery disease

Ding Ding1, Jian Qiu, Xinrui Li

  • 1Corresponding authors: Wenhua Ling, lingwh@mail.sysu.edu.cn.

Diabetes Care
|October 4, 2013
PubMed

Insights

Coronary artery disease (CAD) patients with impaired glucose regulation (IGR) or diabetes face a higher risk of death. Early identification and management of glucose abnormalities are crucial for improving outcomes in CAD patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Known diabetes is a significant risk factor for mortality in patients with coronary artery disease (CAD).
  • The association between other glucose abnormalities and mortality risk in CAD patients remains unclear.
  • Understanding these associations is vital for comprehensive patient management and risk stratification.

Purpose of the Study:

  • To investigate the relationship between various glucose states and the risk of all-cause and cardiovascular disease (CVD) mortality in CAD patients.
  • To determine if glucose abnormalities beyond known diabetes increase mortality risk.

Main Methods:

  • A cohort of 1,726 CAD patients aged 40-85 years was analyzed.
  • Cox proportional hazards regression models were employed to assess the association between baseline glucose status and mortality risk.
  • Multivariable adjustments were made for numerous clinical and demographic factors.

Main Results:

  • Over a median follow-up of 3.1 years, 129 deaths occurred, with 109 from CVD.
  • Impaired glucose regulation (IGR), newly diagnosed diabetes, and known diabetes were associated with significantly increased all-cause and CVD mortality.
  • Specifically, hazard ratios for CVD mortality were 1.89 for IGR, 2.74 for newly diagnosed diabetes, and 2.73 for known diabetes compared to normoglycemia.

Conclusions:

  • CAD patients with IGR, newly diagnosed diabetes, or known diabetes exhibit an elevated risk of cardiovascular disease mortality.
  • These findings underscore the importance of monitoring and managing glucose levels in all CAD patients, not just those with diagnosed diabetes.
Abstract

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