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[Infection rate with adenivirus 1 to 39 in infants and adults]
Insights
Infants frequently develop neutralizing antibodies against common adenoviruses (Ad) types 1, 2, 5, and 6. This study assessed adenovirus infection rates in infants by testing for antibodies against 39 types.
Area of Science:
- Virology
- Immunology
Context:
- Adenoviruses (Ad) are common causes of human infections.
- Infant populations are particularly susceptible to viral infections.
- Understanding adenovirus prevalence is crucial for public health.
Purpose:
- To determine the infection rates of adenoviruses in infants.
- To identify specific adenovirus types prevalent in infants.
- To analyze antibody responses to various adenovirus types.
Summary:
- Sera from 75 infants (8-26 months) were tested for neutralizing antibodies against adenovirus types 1-39.
- High prevalence of antibodies against Ad 1, 2, 5, and 6 was observed.
- A significant association in neutralization reactions for Ad 1, 2, 5, and 6 suggests a subgenus-specific response.
Impact:
- Provides insights into adenovirus epidemiology in infants.
- Highlights common adenovirus types circulating in this age group.
- Informs potential vaccine development and public health strategies.
Abstract:
To study the infection rate with adenoviruses (Ad) in infants, sera from 75 infants aged 8 to 26 months were tested for neutralizing antibodies against Ad 1 to 39. Antibodies against Ad 1, 2, 5, and 6 were frequently found, against Ad 7 more rarely, whereas one serum reacted with each Ad 3, 4, 18, 31, and 37 and none with all other types. A significant association of positive reactions against several or all of Ad 1, 2, 5, and 6 was observed in neutralization, but not in hemagglutination inhibition, probably due to a subgenus-specific antibody response. The titer of neutralizing antibodies in human gammaglobulin was determined as an estimate for the prevalence of Ad 1 to 39 in the general population.