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Studies on human basophil releasability.

G Marone, S Poto, R Giugliano

    International Archives of Allergy and Applied Immunology
    |January 1, 1985
    PubMed
    Summary
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    Basophil releasability, measured by histamine release, varies with donor age and serum IgE levels. Atopic dermatitis patients show heightened basophil responsiveness to anti-immunoglobulin E (anti-IgE).

    Area of Science:

    • Immunology
    • Allergy Research
    • Cellular Biology

    Background:

    • Basophil releasability is a key factor in various diseases.
    • Understanding factors influencing basophil responsiveness is crucial for diagnostics and treatment.
    • Immunoglobulin E (IgE)-mediated responses play a significant role in allergic reactions.

    Purpose of the Study:

    • To investigate the correlation between basophil releasability and donor age.
    • To examine the relationship between serum IgE levels and histamine release.
    • To assess the impact of aging on basophil response to specific stimuli and compare basophil reactivity in atopic dermatitis patients versus controls.

    Main Methods:

    • Measurement of maximum percent histamine release and cell sensitivity to rabbit anti-Fc epsilon (anti-IgE) in normal donors.

    Related Experiment Videos

  • Analysis of serum IgE levels and their correlation with anti-IgE-induced histamine release.
  • Evaluation of basophil response to formyl-Met-Leu-Phe (f-met peptide) in different age groups and comparison of anti-IgE responsiveness in atopic dermatitis patients.

    • Main Results:

    • A correlation was observed between basophil releasability and donor age.
    • A positive correlation between serum IgE levels and anti-IgE-induced histamine release was found in individuals under 20.
    • Basophil response to f-met peptide decreased in individuals over 60, and patients with atopic dermatitis exhibited higher responsiveness to anti-IgE compared to age-matched controls.

    Conclusions:

    • Basophil releasability is influenced by donor age and serum IgE levels, with distinct patterns in younger individuals.
    • Aging affects basophil responsiveness to certain stimuli.
    • Elevated basophil responsiveness to anti-IgE in atopic dermatitis patients suggests a potential role in the pathophysiology of the condition.