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Histamine and human heart.

M Triggiani, A Genovese, C Vigorito

    International Archives of Allergy and Applied Immunology
    |January 1, 1985
    PubMed
    Summary
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    The human heart contains histamine and produces prostanoids. Histamine release and prostanoid production are induced by calcium ionophore, affecting heart rate and blood pressure.

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology

    Background:

    • Human heart tissue contains histamine.
    • The heart synthesizes prostaglandins like PGI2, PGF2 alpha, PGE2, and thromboxane A2 (TxA2).

    Purpose of the Study:

    • To investigate histamine release and prostanoid production in the human heart.
    • To examine the effects of histamine and H1 receptor stimulation on cardiovascular parameters.

    Main Methods:

    • Analysis of histamine content in human right atrial fragments.
    • Induction of histamine release and prostanoid synthesis using Ca2+ ionophore A 23187.
    • Intravenous infusion of histamine in healthy donors.
    • Selective H1 receptor stimulation during cardiac catheterization.

    Main Results:

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    • Human right atrial fragments contain approximately 1.5 micrograms of histamine per gram of wet tissue.
    • Calcium ionophore A 23187 dose-dependently stimulated histamine release and prostanoid production.
    • Histamine infusion increased heart rate and caused ST segment depression.
    • H1 receptor stimulation decreased mean aortic pressure and coronary vascular resistance.

    Conclusions:

    • The human heart actively synthesizes and releases histamine and prostanoids.
    • Histamine plays a role in modulating cardiac function and vascular resistance through H1 receptors.